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Some characters gain unique abilities when they are at locations: although Im sure were going to be getting way more info about how characters and locations are going to be interacting in Into the Inklands, for now we just have to take whats been revealed so far and Ravensburgers word for it that somehow locations and characters are going to have beneficial gameplay mechanics for our decks

As good as Mana Confluence can be as a mana fixer, the life loss adds up

Tangled Colony probably works best in multicolor decks where you have access to some direct damage spells, or at least spells that force creatures of your choice to fight.

It looks like there will be quite a few Pirates in the metagame that this Pan can deal with efficiently