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This can be before blockers are declared, after blockers are declared but before combat damage is dealt, during combat after combat damage is dealt, during the postcombat main phase, during the end step, or, in some unusual cases, during the cleanup step

That said, there are examples of positive IP integration

DIMENSIONS Vertical Orientation: 98mm H* x 64mm W Horizontal Orientation: 74mm H* x 87mm W *please note there is a 1-2mm tolerance on the height of our dividers due to the way they are manufactured

This card only cares about +1/+1 counters versus Pir, but that makes sense with the Mutagen that it comes in with